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Canine Chiari-like malformation : ウィキペディア英語版
Canine Chiari-like malformation
Chiari-like malformation (CM) is the most common cause of foramen magnum obstruction and syringomyelia in dogs. Syringomyelia (SM) is a disease of the spinal cord typified by fluid filled cavities, or syrinxes, within the spinal cord substance. 〔http://www.veterinary-neurologist.co.uk/part1.htm#1〕 The disease is caused by the obstruction of cerebrospinal fluid (CSF), in the nervous system. A situation of high pressure in the spinal cord compared to low pressure outside, leads to fluid accumulation, which eventually forms cavities. 〔http://www.veterinary-neurologist.co.uk/part1.htm#1〕 CM is a condition characterized by the mismatch of size between the brain and the skull. The skull is too small causing part of the brain to descend out of the skull through the opening at its base, crowding the spinal cord.〔http://www.veterinary-neurologist.co.uk/part1.htm#1〕 The cause of CM is not yet fully understood. This disease not only affects thousands of puppies, but a similar condition affects over three hundred thousand children yearly.〔http://www.nyvf.org/index.php/research/current-studies/chiari-screening〕 Therefore, canines are an appropriate model for the treatment of the human condition. 〔http://www.nyvf.org/index.php/research/current-studies/chiari-screening〕
==Symptoms==
The most obvious clinical sign of syringomyelia is pain. Dogs with CM alone do not seem to have signs, but some appear to have facial pain. 〔http://www.veterinary-neurologist.co.uk/part1.htm#1〕 Common symptoms in human patients include, severe headache and neck pain, dizziness, vertigo, disequilibrium, visual disturbances, ringing in the ears, difficulty swallowing, palpitations, sleep apnea, muscle weakness, impaired fine motor skills, chronic fatigue and painful tingling of the hands and feet, pruritus.〔http://www.chiariansunite.org/chiarimalformation.htm#342894460〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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